1. Differentiate the substitution to find an expression for $\mathrm{d}x$ in terms of $\mathrm{d}u$.
x=u1
dudx=−u21⟹dx=−u21du
2. Determine the new limits of integration in terms of $u$.
When x=4,u=41
When x=22,u=221=42
3. Substitute into the integral and simplify to a standard integrable form.
∫224xx2−41dx=∫4241(u1)(u1)2−41(−u21)du=∫4241uu21−4u2−1du=∫4241u(u1−4u2)−1du=∫42411−4u2−1du=∫41421−4u21du
4. Integrate using the standard formula and evaluate the definite integral.
∫41421−4u21du=∫41421−(2u)21du=[21sin−1(2u)]4142=21(sin−1(22)−sin−1(21))=21(4π−6π)=21(123π−2π)=24π
答案\frac{\pi}{24} \text{ (shown)}