A hospital patient is given a pill containing 50 units of antibiotic at 12pm. By 1pm, the number of units of antibiotic in the patient's body has dropped by 12%. By 2pm, a further 12% of the antibiotic remaining in the blood at 1pm is lost. Given that the rate of decrease is such that the amount of antibiotic drops by 12% every one hour, find the amount of antibiotic remaining in the blood at 6pm. A doctor considers prescribing a course of treatment which involves the patient taking the pill every 6 hours over a long period of time. It is given that xn+1=50+(0.88)6 xn ,x_{n+1}=50+(0.88)^6\,x_n\,, where xnx_n denotes the number of units of antibiotic in the body after the nthn^{\text{th}} pill is taken. As n→∞n\to\infty, xn→Lx_n\to L. Determine the value of LL. Show that xn+1>xnx_{n+1}>x_n if xn<Lx_n<L; xn+1<xn if xn>L .x_{n+1}<x_n\ \text{if } x_n>L\,.

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Worked solution

5((i))

1. Determine the time elapsed and the constant decay multiplier.

The number of hours from 12pm to 6pm is 66.
Since the antibiotic decreases by 12%12\% every hour, the multiplier is 1−0.12=0.881 - 0.12 = 0.88.

2. Calculate the amount of antibiotic remaining after 6 hours.

Amount remaining =50×(0.88)6= 50 \times (0.88)^6
=23.220…= 23.220\dots
≈23.2 units\approx 23.2 \text{ units} (to 3 s.f.)

Answer

23.223.2 units

5((ii))((a))

1. Apply the limit to the recurrence relation by setting $x_{n+1}$ and $x_n$ to $L$.

As n→∞n \to \infty, xn→Lx_n \to L. Since xn+1x_{n+1} also approaches the same limit as nn grows indefinitely, we substitute LL into the given recurrence relation:
L=50+(0.88)6LL = 50 + (0.88)^6 L

2. Solve the linear equation for $L$.

L−(0.88)6L=50L - (0.88)^6 L = 50
L(1−0.886)=50L(1 - 0.88^6) = 50
L=501−0.886L = \frac{50}{1 - 0.88^6}
L≈93.354L \approx 93.354
L=93.4 (to 3 s.f.)L = 93.4 \text{ (to 3 s.f.)}

Answer

93.493.4 (to 3 s.f.)

5((ii))((b))

1. Express the difference $x_{n+1} - x_n$ in terms of $L$ and $x_n$.

Consider the difference between consecutive terms:
xn+1−xn=50+(0.88)6xn−xnx_{n+1} - x_n = 50 + (0.88)^6 x_n - x_n
xn+1−xn=50−(1−0.886)xnx_{n+1} - x_n = 50 - (1 - 0.88^6)x_n
From part (ii)(a), the steady-state limit LL satisfies L=50+(0.88)6LL = 50 + (0.88)^6 L, which means 50=L(1−0.886)50 = L(1 - 0.88^6). Substituting this into the equation gives:
xn+1−xn=L(1−0.886)−xn(1−0.886)x_{n+1} - x_n = L(1 - 0.88^6) - x_n(1 - 0.88^6)
xn+1−xn=(1−0.886)(L−xn)x_{n+1} - x_n = (1 - 0.88^6)(L - x_n)

2. Deduce the first inequality when $x_n < L$.

Since 0.88<10.88 < 1, the constant term (1−0.886)>0(1 - 0.88^6) > 0.
If xn<Lx_n < L, then (L−xn)>0(L - x_n) > 0.
Therefore, the product is positive:
(1−0.886)(L−xn)>0(1 - 0.88^6)(L - x_n) > 0
xn+1−xn>0x_{n+1} - x_n > 0
xn+1>xn (Shown)x_{n+1} > x_n \text{ (Shown)}

3. Deduce the second inequality when $x_n > L$.

Similarly, if xn>Lx_n > L, then (L−xn)<0(L - x_n) < 0.
Therefore, the product is negative:
(1−0.886)(L−xn)<0(1 - 0.88^6)(L - x_n) < 0
xn+1−xn<0x_{n+1} - x_n < 0
xn+1<xn (Shown)x_{n+1} < x_n \text{ (Shown)}

Answer

As shown in the working.

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