Glucose is a type of sugar in our blood and our body uses it for energy. Having low sugar in the blood for long periods of time can cause health problems if it is not treated. At 10:00 am, a patient is given glucose via an intravenous drip at a constant rate of rr units of glucose per hour. It is known that the rate at which the glucose in the blood stream is absorbed by the body, is proportional to the amount of glucose present in the blood stream. At the start of the treatment, the patient has x0x_0 units of glucose in his blood stream. It is given that xx denotes the amount of glucose present in the blood stream of the patient at time tt hours after he starts the treatment.

  1. (a)

    Form a differential equation in xx and show that x=(x0−rk)e−kt+rkx = \left( x_0 - \dfrac{r}{k} \right)e^{-kt} + \dfrac{r}{k} where kk is a positive constant.

  2. (b)

    State the theoretical limiting value of xx if the patient is given the treatment over a long period.

  3. (c)

    Sketch the graph of xx for t≥0t \ge 0.

  4. (d)

    At what time (to the nearest minute), would the glucose in his blood stream first exceed 90% of the value found in part (b)?

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Worked solution

10(a)

1. Formulate the differential equation based on the given rates.

The rate at which glucose is added is rr.
The rate at which it is absorbed is proportional to xx, so the rate out is kxkx, where kk is a positive constant.
dxdt=Rate in−Rate out\frac{dx}{dt} = \text{Rate in} - \text{Rate out}
dxdt=r−kx\frac{dx}{dt} = r - kx

2. Separate variables and integrate both sides.

∫1r−kx dx=∫1 dt\int \frac{1}{r - kx} \, dx = \int 1 \, dt
−1kln⁡∣r−kx∣=t+C-\frac{1}{k} \ln |r - kx| = t + C

3. Express the general solution without logarithms.

ln⁡∣r−kx∣=−kt−kC\ln |r - kx| = -kt - kC
r−kx=±e−kCe−ktr - kx = \pm e^{-kC} e^{-kt}
Let A=±e−kCA = \pm e^{-kC}.
r−kx=Ae−ktr - kx = A e^{-kt}

4. Apply the initial condition to find the particular solution.

At t=0,x=x0t = 0, x = x_0:
r−kx0=Ae0  ⟹  A=r−kx0r - kx_0 = A e^{0} \implies A = r - kx_0
Substituting AA back into the equation:
r−kx=(r−kx0)e−ktr - kx = (r - kx_0) e^{-kt}
kx=r−(r−kx0)e−ktkx = r - (r - kx_0)e^{-kt}
x=rk−(rk−x0)e−ktx = \frac{r}{k} - \left(\frac{r}{k} - x_0\right)e^{-kt}
x=(x0−rk)e−kt+rk(shown)x = \left(x_0 - \frac{r}{k}\right)e^{-kt} + \frac{r}{k} \quad \text{(shown)}

Answer

dxdt=r−kx\frac{dx}{dt} = r - kx

10(b)

1. Determine the behaviour of $x$ as $t \to \infty$.

As t→∞t \to \infty, since kk is a positive constant, e−kt→0e^{-kt} \to 0.

Therefore, x→(x0−rk)(0)+rk=rkx \to \left( x_0 - \frac{r}{k} \right)(0) + \frac{r}{k} = \frac{r}{k}.

Answer

rk\frac{r}{k}

10(c)

1. Determine the intercepts and asymptotes of the graph.

At t=0t = 0, x=x0x = x_0. Thus, the vertical intercept is (0,x0)(0, x_0).
From part (b), as t→∞t \to \infty, the theoretical limiting value is x=rkx = \frac{r}{k}. Thus, there is a horizontal asymptote at x=rkx = \frac{r}{k}.

2. Deduce the shape of the curve based on the context and sketch the graph.

Since the patient is receiving treatment for low blood sugar, the initial amount x0x_0 is less than the target stable level rk\frac{r}{k}. This means (x0−rk)\left( x_0 - \frac{r}{k} \right) is a negative constant.
As tt increases, e−kte^{-kt} decreases, so the expression (x0−rk)e−kt\left( x_0 - \frac{r}{k} \right)e^{-kt} approaches 00 from below. Therefore, xx increases over time, starting from x0x_0 and asymptotically approaching rk\frac{r}{k}.

Key features for the sketch:

  1. Axes correctly labelled tt and xx.
  2. A horizontal dotted line for the asymptote at x=rkx = \frac{r}{k}.
  3. A concave-down curve starting at (0,x0)(0, x_0) and increasing towards x=rkx = \frac{r}{k}.
Answer

[A sketch is drawn with a horizontal tt-axis and a vertical xx-axis. A horizontal dotted line is marked at x=rkx = \frac{r}{k}. A smooth concave-down curve starts on the vertical axis at x0x_0 (where x0<rkx_0 < \frac{r}{k}) and increases, approaching the asymptote x=rkx = \frac{r}{k} as t→∞t \to \infty.]

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